Synthesis of N-Biheteroarenes via Acceptorless Dehydrogenative Coupling of Benzocyclic Amines with Indole Derivatives

The Journal of Organic Chemistry
Xiuwen ChenMin Zhang

Abstract

Here, via a strategy of in situ capture of partially dehydrogenated cyclic amine motifs, we present an acceptorless dehydrogenative coupling of benzocyclic amines with indole derivatives that enables to access various quinoline-indole linked N-biheteroarenes in an efficient manner. The catalytic transformation is characteristic of operational simplicity, a readily available catalyst system, good substrate and functional compatibility, mild conditions, high atom efficiency, and no need for oxidant and halogenated coupling agents.

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Citations

Jul 31, 2019·Organic & Biomolecular Chemistry·Shaohua JiangXiuwen Chen
Nov 13, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Dhrubajit BorahPankaj Das
Nov 30, 2019·The Journal of Organic Chemistry·Xiuwen ChenYibiao Li

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