Synthesis of N-(methoxycarbonylthienylmethyl)thioureas and evaluation of their interaction with inducible and neuronal nitric oxide synthase.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Ghadeer A R Y SuaifanMichael D Threadgill

Abstract

Two isomeric N-(methoxycarbonylthienylmethyl)thioureas were synthesised by a sequence of radical bromination of methylthiophenecarboxylic esters, substitution with trifluoroacetamide anion, deprotection, formation of the corresponding isothiocyanates and addition of ammonia. The interaction of these new thiophene-based thioureas with inducible and neuronal nitric oxide synthase was evaluated. These novel thienylmethyl-thioureas stimulated the activity of inducible Nitric Oxide Synthase (iNOS).

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Citations

Sep 8, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carla I NietoDarío Acuña-Castroviejo
May 23, 2012·Journal of Molecular Graphics & Modelling·Ghadeer A R Y SuaifanMutasem O Taha
Jan 13, 2015·Organic & Biomolecular Chemistry·Yeming JuSangho Koo
Jun 9, 2016·Interdisciplinary Sciences, Computational Life Sciences·Mukesh C Sharma, S Sharma

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Methods Mentioned

BETA
NMR

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