PMID: 2096799Dec 1, 1990Paper

Synthesis of N-substituted 3'-amino-3'-deoxythymidines and their biological evaluation against HIV

Archiv der Pharmazie
M S MotawiaC M Nielsen

Abstract

Treatment of 3'-amino-3'-deoxythymidine (1) with carboxylic acid anhydrides afforded the corresponding acylamino derivatives 2a-f. Reaction of 1 with a variety of isothiocyanates led to the corresponding thioureido derivatives 3a-i. Also, conversion of 1 into 3'-carbylamino-3'-deoxythymidine (7) is reported. The compounds 2, 3, and 8 were evaluated for their anti-HIV activity in MT-4 cells, but did not show sufficient efficacy.

References

Mar 1, 1989·Journal of Medicinal Chemistry·E PalominoJ P Horwitz
May 9, 1986·Science·J CoffinP Vogt
Aug 1, 1987·Journal of Medicinal Chemistry·P HerdewijnH Vanderhaeghe
Jan 1, 1972·Journal of Pharmaceutical Sciences·C Hansch, W J Dunn
Jan 1, 1973·Journal of Pharmaceutical Sciences·C Hansch, J M Clayton
Dec 1, 1967·Biochemical Pharmacology·A E Bird, A C Marshall

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