Synthesis of nalidixic acid based hydrazones as novel pesticides

Journal of Agricultural and Food Chemistry
Nisha AggarwalJ M Khurana

Abstract

Thirty-one substituted hydrazones of nalidixic acid hydrazide were synthesized and characterized by spectral techniques. These compounds were evaluated for various biological activities, namely, fungicidal, insecticidal, and nitrification inhibitory activities. The antifungal activity was evaluated against five pathogenic fungi, namely, Rhizoctonia bataticola , Sclerotium rolfsii , Rhizoctonia solani , Fusarium oxysporum , and Alternaria porii . They showed maximum inihibition against A. porii with ED(50) = 34.2-151.3 microg/mL. The activity was comparable to that of a commercial fungicide, hexaconazole (ED(50) = 25.4 microg/mL). They were also screened for insecticidal activity against third-instar larvae of Spodoptera litura and adults of Callosobruchus maculatus and Tribollium castaneum . Most of them showed 70-100% mortality against S. litura through feeding method at 0.1% dose. These compounds were not found to be effective nitrification inhibitors.

References

Nov 1, 1973·Journal of Medicinal Chemistry·C HanschE J Lien
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·K O'DonnellR C Ploetz
Nov 2, 2005·European Journal of Medicinal Chemistry·Gaurav Grover, Suvarna G Kini
Nov 3, 2005·Bioorganic & Medicinal Chemistry Letters·Patricia MelnykPhilippe Grellier
Mar 16, 2006·Journal of Agricultural and Food Chemistry·Tarun Kumar Chattapadhyay, Prem Dureja
Jul 31, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Ahmet OzdemirGokalp Iscan
Oct 10, 2008·Journal of Agricultural and Food Chemistry·Rajesh KumarT Arivalagan
Aug 26, 2009·Journal of Agricultural and Food Chemistry·Nisha AggarwalDiwan S Rawat

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Citations

Nov 17, 2012·European Journal of Medicinal Chemistry·Jitender M KhuranaChitra Srivastava
Jul 6, 2016·Acta Crystallographica. Section C, Structural Chemistry·F R G BergaminiP P Corbi
Sep 26, 2020·Journal of Agricultural and Food Chemistry·Fangli GangJiwen Zhang
Jun 13, 2020·Journal of Agricultural and Food Chemistry·Dexia LuoJian Wu

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