Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity

Bioorganic & Medicinal Chemistry
Maria T CoccoOmar Cauli

Abstract

A new series of 2-arylamino-6-trifluoromethyl-3-carboxylic acid derivatives was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to aspirin, ibuprofen and flufenamic acid some of the new compounds exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect.

Citations

Sep 3, 2013·Chemical & Pharmaceutical Bulletin·Nadia Abdalla KhalilSawsan Abo-Bakr Zaitone
Sep 26, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Nasir UllahCarlos A Velázquez-Martínez
Mar 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Angela CoronaEnzo Tramontano
Feb 2, 2013·Chemical & Pharmaceutical Bulletin·Khaled Abouzid Mohamed AbouzidSawsan Abo-Bakr Zaitone

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