Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity

European Journal of Medicinal Chemistry
Nasir ali Shafakat AliMazahar Farooqui

Abstract

We are reporting herein for the first time the synthesis of α-aminophosphonates containing Indazole moiety in two steps. In the first step, imines of substituted N-benzylidene-1-methyl-1H-indazole-3-carbohydrazide are synthesized and in the next step it has converted to α-aminophosphonates using chlorotrimethylsilane (TMSCl) and triethyl phosphite. Some of the synthesized derivatives are evaluated for antibacterial activity against different bacterial strains.

References

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Citations

Oct 8, 2013·European Journal of Medicinal Chemistry·Xiao-Chao HuangYe Zhang
Nov 26, 2015·Acta Crystallographica. Section E, Crystallographic Communications·Assoman KouakouLahcen El Ammari
Oct 1, 2016·The Journal of Organic Chemistry·Kankanala RamakrishnaChinnappan Sivasankar
Aug 27, 2019·Chemistry : a European Journal·Tsubasa InokumaKen-Ichi Yamada
May 16, 2014·Acta Crystallographica. Section E, Structure Reports Online·Assoman KouakouLahcen El Ammari
Jul 28, 2020·Data in Brief· DukanyaKanchugarakoppal S Rangappa
Sep 15, 2020·The Journal of Organic Chemistry·Taehyun Lim, Byeong Moon Kim
Aug 31, 2013·Bioorganic & Medicinal Chemistry Letters·Xiao-Chao HuangYe Zhang

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