Synthesis of New Antibacterial Cubane-based Nanocomposite and its Application in Combination Cancer Therapy

Anti-cancer Agents in Medicinal Chemistry
Elham ZakerzadehMehrdad Mahkam

Abstract

The need for therapeutically effective anticancer drug delivery systems constantly persuades researchers to explore novel strategies. In this study a novel cubane based antibacterial nanocomposite was tailored as dual chemotherapy drug delivery vesicle in order to increase the therapeutic outcome in cancer therapy. The physico-chemical characterization of engineered nanocarrier was assessed by Fourier transforms infrared spectroscopy (FTIR), Hydrogen nuclear magnetic resonance spectroscopy (1H NMR), Thermogravimetric analysis (TGA), and Field emission scanning electron microscopy-energy dispersive using X-ray (FESEMEDX). The antibacterial activity of novel developed nanocomposite was tested by determining minimum inhibitory concentration (MIC) values against Pseudomonas aeruginosa, Escherichia Coli and Candida albicans. In order to investigate the efficacy of novel engineered nanocomposite (with average particle size of 50 nm) as dual anticancer drug delivery, DOX and MTX were bind to nanocarrier with encapsulation efficiency and loading content of around 97.3 ± 2.7% and 20.8 ± 1.6 %, respectively. Dual drugs released simultaneously with distinct tumor targeted, pH responsive sustained release manner. Moreover, the probable ant...Continue Reading

Citations

Aug 24, 2018·Journal of Medicinal Chemistry·Tristan A ReekieMichael Kassiou

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