Synthesis of new coumarin 3-(N-aryl) sulfonamides and their anticancer activity

Bioorganic & Medicinal Chemistry Letters
Natala Srinivasa ReddyM V Ramana Reddy

Abstract

Synthesis of coumarin 3-(N-aryl) sulfonamides was accomplished either by Knoevenagel condensation of anilinosulfonylacetic acids with suitable salicylaldehydes or by the reaction of methyl anilinosulfonylacetates with substituted salicylaldehydes in presence of a catalytic amount of a base. All the compounds tested for antiproliferative activity in different cancer cell lines have shown GI(50) values less than 100 microM.

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