Synthesis of new oxadiazole, pyrazole and pyrazolin-5-one bearing 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetohydrazide analogs as potential antibacterial and antifungal agents

Annales pharmaceutiques françaises
M MaheshP Venkata Ramana

Abstract

Two series of diversely substituted phenyldiazenyl(2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetyl)3,5-dimethyl-1H-pyrazole 11a-g and phenyldiazenyl-1-(2-(4-methyl-2-oxo-4-chromen-7-yloxy)acetyl)-3-methyl-1H-pyrazol-5(4)H-one 12a-j were synthesized. All these compounds were characterized by IR, NMR, mass spectra and elemental analyses. The compounds were evaluated for their in vitro antibacterial activity against some Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis, Gram-negative bacteria, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and screened for antifungal activity against A. niger, U. maydis. The compounds showed moderate to very good antibacterial activities.

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Citations

Jul 2, 2019·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Mohammed AlbrattyHassan Ahmed Alhazmi

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