Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors

Bioorganic & Medicinal Chemistry
Andrea AngeliClaudiu T Supuran

Abstract

A novel series of acyl selenoureido benzensulfonamides was evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors against the human (h) isoforms hCA I, II, VII and IX, which are involved in a variety of diseases such as glaucoma, retinitis pigmentosa, epilepsy and tumors etc. These compounds showed excellent inhibitory activity for these isoforms, with several low nanomolar derivatives identified against all of them. Furthermore, the selenoureido group may provide an antioxidant activity to these enzyme inhibitors.

Citations

Jan 16, 2020·Antioxidants·Ana Carolina RuberteCarmen Sanmartín
Aug 12, 2019·European Journal of Medicinal Chemistry·Damiano TaniniClaudiu T Supuran
Sep 2, 2019·Bioorganic Chemistry·Y Kalisha ValiClaudiu T Supuran
Nov 7, 2019·European Journal of Medicinal Chemistry·Damiano TaniniClaudiu T Supuran
Jul 25, 2019·Bioorganic Chemistry·Immo SerbianRené Csuk
Jun 3, 2021·International Journal of Molecular Sciences·Andrea AngeliClaudiu T Supuran
May 31, 2021·Bioorganic & Medicinal Chemistry Letters·Andrea AngeliClaudiu T Supuran
Jul 4, 2021·European Journal of Medicinal Chemistry·Hongyan ChuaiMinhang Xin
Dec 11, 2020·The Journal of Organic Chemistry·Lai LiXuefeng Jiang

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