Synthesis of novel polyaminoetherurethaneureas and development of antithrombogenic material by their chemical modifications

Journal of Biomedical Materials Research
R ShibutaY Imanishi

Abstract

Novel polyaminoetherurethaneureas containing tertiary amino groups in the main chain were synthesized (PAEUU), quaternized (Q-PAEUU), and heparinized (H-PAEUU). Films of PAEUU showed a microphase separation, which was influenced by the quaternization and the heparinization. With increasing content of amino group, the water content of Q-PAEUU and the heparin content of H-PAEUU increased. The heparin-releasing rate from H-PAEUU into physiological saline solution was slow, but increased with increasing content of quaternary ammonium groups in the polymer. The water content, the heparin adsorption, and the heparin-releasing rate were controlled by the kind of quaternizing agent. The antithrombogenicity of the polyurethaneureas was improved by quaternization and very much by heparinization, and affected by the kind of quaternizing agent. Heparinization was indispensable for achieving antithrombogenicity of the polymer, although the antithrombogenicity of H-PAEUU was affected more strongly by the water content than by the heparin content. The surface free energy of these polymer films was also investigated.

References

Jan 1, 1973·Transactions - American Society for Artificial Internal Organs·J D AndradeJ B Hibbs
Sep 1, 1973·Journal of Biomedical Materials Research·S D Bruck
May 1, 1972·Journal of Biomedical Materials Research·Y Imai, Y Nose
Sep 1, 1970·Journal of Biomedical Materials Research·D W MarshallH J Bixler
Sep 1, 1982·Journal of Biomedical Materials Research·C D EbertS W Kim

❮ Previous
Next ❯

Citations

Jul 1, 1995·Journal of Biomedical Materials Research·A GutowskaS W Kim
Jan 1, 1996·Journal of Biomaterials Science. Polymer Edition·W MarconiD Romoli
Jun 28, 2005·Colloids and Surfaces. B, Biointerfaces·Anfeng WangK Y Simon Ng
Apr 1, 1987·Journal of Biomaterials Applications·C P SharmaM C Sunny
Apr 1, 1988·Journal of Biomaterials Applications·R EloyJ Baguet
Oct 1, 1987·Journal of Biomaterials Applications·Y Ito
Dec 7, 2010·Journal of Materials Chemistry·Melissa M ReynoldsMark E Meyerhoff
Oct 1, 1986·Journal of Biomedical Materials Research·Y ItoY Imanishi
May 1, 1993·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·M F Sigot-LuizardR C Eberhart
Mar 15, 2006·Biomacromolecules·Melissa M ReynoldsMark E Meyerhoff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.