PMID: 20644596Jul 21, 2010Paper

Synthesis of novel selenium-containing sulfa drugs and their antibacterial activities

Bioorganicheskaia khimiia
Sh H Abdel-Hafez

Abstract

Synthesis of 3-[4-(N-substituted sulfamoyl)phenyl]-3,4-dihydro-4-oxo-7,9-dimethylpyrido[3',2':4,5]selenolo[3,2-d]pyrimidines, 7-[4-(N-substituted sulfamoyl)phenyl]-7,8-dihydro-8-oxo-3,4-diphenylpyrimido[4',5':4,5]selenolo [2,3-c]pyridazines and 1-[4-(N-substituted sulfamoyl)phenyl]-1,11-dihydro-11-oxo-4-methylpyrimido[4',5':4,5]selenolo[2,3-b]quinolines is reported. 4-Amino-N-pyrimidine-2-ylbenzene sulfonamide (a), 4-amino-N-(2,6-dimetnylpyrimidin-4-yl)benzene sulfonamide (b), N-[(4-aminophenyl)sulfonyl] acetamide (c) with N-ethoxymethyleneamino of selenolo pyridine, selenolo pyridazine and selenolo quinoline derivatives respectively were obtained starting from 1-amino-N-substituted sulfanilamides. Spectroscopic data (IR, (1)H NMR, (13)C NMR and Mass spectral) confirmed the structure of the newly synthesized compounds. Substituted pyrimidines, pyridazines and quinolines were screened for antibacterial activity against gram-positive and gram-negative bacteria. Selenolo derivative of N-[(4-aminophenyl)sulfonyl] acetamide (substitutent of sulfacetamide c) showed strong bactericidal effect against all the tested organisms. Selenolo[3,2-d]pyrimidin (substitutent a) showed a good bactericidal effect against Serratia marcescens, Staph...Continue Reading

References

Jan 1, 1976·Annual Review of Pharmacology and Toxicology·T H Maren
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Mar 30, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mamoru KoketsuHideharu Ishihara

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Citations

Feb 2, 2018·The Open Medicinal Chemistry Journal·Kamal ShahPradeep Mishra
Sep 9, 2011·Bioorganicheskaia khimiia·S H Abdel-HafezM R E Aly
Jan 19, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Edward R T Tiekink

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