Synthesis of novel sulfonamide analogs containing sulfamerazine/sulfaguanidine and their biological activities

Journal of Enzyme Inhibition and Medicinal Chemistry
Burak AdayMuharrem Kaya

Abstract

Sulfamerazine and sulfaguanidine are clenched with p-nitrobenzoyl chloride and the products obtained are reduced to NaxS in ethanol-water. Novel sulfonamides (6a-g and 9a-g) were synthesized by the reaction of these reduced products (4 and 8) with various sulfonyl chlorides (5a-g). The structures of these compounds were characterized using spectroscopic analysis (IR, (1)H-NMR, (13)C-NMR and HRMS) technique. Antimicrobial activity of sulfonamides (3, 4, 7, 8, 6a-g and 9a-g) was evaluated by the agar diffusion method. These compounds showed antimicrobial activity against tested microorganism strains (Gram-positive bacteria, clinic isolate and yeast and mold). Compounds 9d, 9e, 9a, 6d and 6e showed particularly antimicrobial activity against tested Gram-positive (Bacillus cereus and B. subtilis) and Gram-negative (Enterobacter aerogenes) bacteria.

References

Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Aug 19, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Muharrem KayaMetin Bülbül
Jul 19, 2012·Journal of Enzyme Inhibition and Medicinal Chemistry·Muharrem KayaHatice Bekci
Aug 3, 2012·Bioorganic & Medicinal Chemistry·Robert L ArechederraShelley D Minteer
Mar 16, 2013·Expert Opinion on Therapeutic Patents·Fabrizio Carta, Claudiu T Supuran
Apr 24, 2013·Expert Opinion on Therapeutic Patents·Andrea ScozzafavaFabrizio Carta
May 16, 2013·Expert Opinion on Therapeutic Patents·Simona Maria MontiGiuseppina De Simone
Jun 12, 2013·Toxins·Nalini Ramarao, Vincent Sanchis

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Citations

May 31, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Ramazan UlusMetin Bülbül

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