Synthesis of novel tetrandrine derivatives and their inhibition against NSCLC A549 cells

Journal of Asian Natural Products Research
Qian-Hao YangZheng-Bao Zhao

Abstract

A series of novel tetrandrine (Tet) derivatives were synthesized through Suzuki -Miyaura reaction and evaluated for their cytotoxicity against human non-small cell lung carcinoma (NSCLC) A549 cells. Interestingly, most of derivatives showed similar cytotoxicity to Tet against NSCLC A549 cells, and particularly, compounds Y5, Y6, Y9 and Y11 showed the most significant cytotoxic effects with IC50 values ranging from 3.87 to 4.66 mM. The present study is expected to contribute to the future design of more effective anticancer agents in lung cancer chemotherapy.

References

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Citations

Feb 25, 2020·Organic & Biomolecular Chemistry·Ramona SchützFranz Bracher

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Methods Mentioned

BETA
NMR
column chromatography

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