Synthesis of oligonucleotide derivatives using ChemMatrix supports

Chemistry & Biodiversity
Stefania MazziniRamon Eritja

Abstract

The synthesis of oligonucleotides on poly(ethylene glycol)-based (ChemMatrix) supports was studied. Results show that oligonucleotides can be indeed prepared in good yields using slightly modified synthesis cycles and automated DNA synthesizers. The use of these supports for the synthesis of oligonucleotide-peptide conjugates and for the ligation of oligonucleotides using Cu(+)-catalyzed cycloadition reactions is reported. Moreover, these supports can be used for the preparation of oligonucleotides in anhydrous solvents, followed by hybridization of the complementary sequences in aqueous buffers.

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Dec 18, 2007·Chemistry & Biodiversity·Margarita Alvira, Ramon Eritja

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Citations

Jul 28, 2009·Journal of Peptide Science : an Official Publication of the European Peptide Society·Gerardo A AcostaFernando Albericio
Sep 21, 2010·Journal of Peptide Science : an Official Publication of the European Peptide Society·Yésica García-RamosFernando Albericio
Nov 24, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna AviñóRamon Eritja
Sep 25, 2008·Angewandte Chemie·Philipp M E GramlichThomas Carell
Mar 24, 2010·Chemical Society Reviews·Afaf H El-Sagheer, Tom Brown
Sep 25, 2010·The Journal of Organic Chemistry·Santiago GrijalvoRamon Eritja

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