Synthesis of oxazolidine-2,4-diones by a tandem phosphorus-mediated carboxylative condensation-cyclization reaction using atmospheric carbon dioxide

Chemical Communications : Chem Comm
Wen-Zhen ZhangXiao-Bing Lu

Abstract

The oxazolidine-2,4-dione motif is found frequently in biologically important compounds. A tandem phosphorus-mediated carboxylative condensation of primary amines and α-ketoesters/base-catalyzed cyclization reaction have been developed. These processes provide a novel and convenient access to various oxazolidine-2,4-diones in a one-pot fashion using atmospheric carbon dioxide and readily available substrates under very mild and transition-metal-free conditions.

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Citations

Jul 16, 2015·Organic Letters·Sunewang Rixin Wang, Alexander T Radosevich
Oct 19, 2016·Chemistry : a European Journal·Chun-Xiao GuoXiao-Bing Lu
Nov 28, 2018·Chemical Society Reviews·Sheng Wang, Chanjuan Xi
Nov 23, 2018·Organic & Biomolecular Chemistry· Preeti, Krishna Nand Singh
Jul 1, 2015·Beilstein Journal of Organic Chemistry·Wen-Zhen ZhangXiao-Bing Lu
Apr 27, 2017·Organic & Biomolecular Chemistry·Minfang XiaJiang Cheng
Aug 7, 2020·Chemical Communications : Chem Comm·Jiayong ZhangZhengjie He

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