Synthesis of PAF-acether and blood volume changes in gram-negative sepsis

Immunopharmacology
P IñarreaM Sánchez-Crespo

Abstract

Gram-negative sepsis was induced in rats by intraperitoneal injection of Escherichia coli. The development of bacterial peritonitis and septicemia was monitored by counting the number of peritoneal cells and by performing cultures of blood samples. Mortality reached a 50% rate when rats were injected with 2 X 10(8) colony-forming units. Rats injected with the doses of bacteria which induced mortality showed a time- and dose-dependent increase of vascular permeability as judged by the presence of abundant peritoneal exudate and by the depletion of the circulating volume. In order to know whether the generation of PAF-acether could be involved in the development of the permeability changes, the formation of this mediator was measured in the peritoneal cells and spleen of animals at different times and in response to different doses of E. coli. Significant amounts of PAF-acether could be obtained preceding the development of blood volume depletion in response to the injection of doses of E. coli which induced both mortality and the development of permeability. These data suggest that PAF-acether might be one of the inflammatory mediators involved in the pathogenesis of the hemodynamic changes observed in endotoxemia.

References

Oct 29, 1979·Biochemical and Biophysical Research Communications·M L BlankE E Muirhead
Oct 1, 1974·The Journal of Clinical Investigation·K L BrighamN C Staub
Jan 21, 1983·European Journal of Pharmacology·P BessinJ Benveniste
Sep 1, 1983·The Journal of Clinical Investigation·R WinnJ Hildebrandt
Jun 1, 1981·The Journal of Antimicrobial Chemotherapy·R L Simmons, D H Ahrenholz
Apr 1, 1962·The Journal of Pathology and Bacteriology·B J NORTHOVER, G SUBRAMANIAN

Citations

Oct 1, 1991·Inflammation·N KalmovarinF Yang
Dec 1, 1991·Lipids·R RabinoviciG Feuerstein
Sep 23, 1987·European Journal of Pharmacology·D A HandleyR N Saunders
Jun 10, 1988·European Journal of Pharmacology·J LefortB B Vargaftig
Jan 3, 1991·European Journal of Pharmacology·F SquadritoA P Caputi
Mar 1, 1994·Prostaglandins·D L KaminskiY G Deshpande
Jan 1, 1988·Molecular Aspects of Medicine·N C OlsonC E McCall
Sep 1, 1990·Immunopharmacology·H A LeaverP L Yap
Jan 31, 1989·Biochemical and Biophysical Research Communications·J G FilepT Mózes
Mar 1, 1996·Clinics in Chest Medicine·R J Panos, S K Baker
Feb 26, 1998·American Journal of Respiratory Cell and Molecular Biology·J M MiotlaP G Hellewell
May 1, 1987·The Journal of Clinical Investigation·S W ChangN F Voelkel
May 1, 1989·The Journal of Clinical Investigation·F Lopez DiezM Sanchez Crespo
May 1, 1991·Journal of Veterinary Internal Medicine·D D Morris
Feb 15, 1991·Thrombosis Research·J G FilepE Földes-Filep
Dec 1, 1989·Resuscitation·D HosfordP Braquet
Dec 1, 1987·Thrombosis Research·F BussolinoA Bosia
Jul 1, 1998·The Annals of Thoracic Surgery·A K QayumiC W Kim
Sep 1, 1987·British Journal of Pharmacology·B J WhittleJ L Wallace
Jun 26, 2010·Journal of Medical Microbiology·H M H N BandaraL P Samaranayake
Feb 23, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·U Pattanaik, K Prasad
Jan 1, 1992·British Journal of Pharmacology·S Fernández-GallardoM Sánchez Crespo
Feb 7, 2002·Cardiovascular Drug Reviews·E Tibiriçá

Related Concepts

Metazoa
Bacterial Infections
Vascular Permeability
High Pressure Liquid Chromatography Procedure
Escherichia Coli Infections
Platelet Activating Factor
August Rats
Spleen
Pyemia
Rats, Laboratory

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.