Synthesis of pharmaceutically important condensed heterocyclic 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivatives as antimicrobials

European Journal of Medicinal Chemistry
S Nanjunda SwamyKanchugarakoppal S Rangappa

Abstract

The two series of 4,6-disubstituted 1,2,4-triazolo-1,3,4-thiadiazole derivatives 2(a-e) and 3(a-e) were synthesized and characterized using IR, (1)H-NMR, CHNS analysis and by single crystal X-ray crystallographic studies. The compound 6-(2-chloro-phenyl)-3-ethyl-[1,2,4]triazole[3,4-b]thiadiazole 2b has been characterized by single crystal X-ray diffraction method. The compound crystallizes in monoclinic space group P2(1)/c with a cell parameters a = 11.879(1) Angstroms, b = 15.112(2) Angstroms, c = 13.95(2) Angstroms, Z = 8 and the final R factor is R1= 0.0524. The structure exhibits both intra and intermolecular hydrogen bonds. The title compounds were checked for their efficacy as antimicrobials in vitro. Compounds 2b, 2c, 2d, 3b, 3c and 3d showed significant inhibition against all the strains tested, when compared to standard drugs.

References

Jun 19, 2004·Bioorganic & Medicinal Chemistry Letters· BasappaK S Rangappa

❮ Previous
Next ❯

Citations

Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·Hoong-Kun FunB Kalluraya
Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·Hoong-Kun FunS M Dharmaprakash
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Hoong-Kun FunArun M Isloor
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Aamer Saeed, Michael Bolte
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Aamer SaeedMasood Parvez
Jan 1, 2013·International Journal of Medicinal Chemistry·Bhawna SharmaUpendra Kumar Sharma
Aug 26, 2014·European Journal of Medicinal Chemistry·Mona M Kamel, Nadia Y Megally Abdo
Mar 31, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lidija KosychovaŽilvinas Anusevičius
Jul 17, 2018·The Open Medicinal Chemistry Journal·Rajpurohit AnantacharyaVinitha Ramanath Pai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.