Synthesis of phospholipase A2 inhibitory biflavonoids

Bioorganic & Medicinal Chemistry Letters
Jianjun ChenHaeil Park

Abstract

A series of C-C biflavones was designed to investigate the relationship between structural array of different flavone-flavone subunit linkage and the inhibitory activity against phospholipase A2 (PLA2). Among six classes of C-C biflavones designed, four classes of C-C biflavones, which have flavone-flavone subunit linkages at A ring-A ring, A ring-B ring, B ring-B ring, and B ring-C ring, were synthesized. The synthetic biflavones exhibited somewhat different inhibitory activities against sPLA2-IIA. Among them, the biflavone a having a C-C 4'-4' linkage showed comparable inhibitory activity with that of the natural biflavonoid, ochnaflavone, and 7-fold stronger activity than that of amentoflavone. Further chemical modification is being carried out in order to obtain the chemically optimized biflavonoids.

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Citations

Apr 15, 2008·Archives of Pharmacal Research·Hyun Pyo KimSam Sik Kang
Dec 31, 2010·Archives of Pharmacal Research·Santosh K GurungHaeil Park
Jul 16, 2014·European Journal of Medicinal Chemistry·Manjinder SinghOm Silakari
Aug 8, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tawona N ChinembiriJeanetta du Plessis
Apr 24, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mamoalosi A Selepe, Fanie R Van Heerden
May 18, 2017·Organic & Biomolecular Chemistry·Tze Han SumDavid R Spring
Dec 23, 2008·Biochemical and Biophysical Research Communications·Juneyoung LeeDong Gun Lee
Oct 23, 2015·Organic & Biomolecular Chemistry·Mariia MiliutinaPeter Langer
Apr 21, 2009·Medicinal Research Reviews·Raju Gautam, Sanjay M Jachak
Dec 26, 2018·Chemical Biology & Drug Design·Shengde ZhangAixia Yan
Nov 21, 2007·Chemistry & Biodiversity·Mohammed RahmanUmesh R Desai
Mar 3, 2007·The Journal of Pharmacy and Pharmacology·Haeil ParkHyun Pyo Kim
Aug 21, 2019·Organic & Biomolecular Chemistry·Kui LuPeng Yu
Sep 11, 2007·Bioorganic & Medicinal Chemistry·Tae Chul MoonHyeun Wook Chang
Sep 27, 2017··Gang WangTian-Qing Gan

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