PMID: 11933114Apr 5, 2002Paper

Synthesis of plumbagin derivatives and their inhibitory activities against Ehrlich ascites carcinoma in vivo and Leishmania donovani Promastigotes in vitro

Phytotherapy Research : PTR
Banasri HazraBiswanath Dinda

Abstract

Plumbagin, a plant-derived bioactive naphthoquinonoid compound, was converted to a hydroquinonoid derivative, which was studied for its tumour-inhibitory and antileishmanial activities for the first time. A similar chemical transformation was undertaken on an analogous dimeric compound, diospyrin, and its bioassay results were compared with those of the plumbagin derivative. Synthesis of the derivative of plumbagin did not result in a marked enhancement of the tumour-inhibitory activity, whereas the improvement was obvious in the case of diospyrin vis à vis its hydroquinonoid analogue. The conversion of diospyrin to the hydroquinonoid compound also led to a substantial increase in the antileishmanial activity, while a similar conversion of plumbagin failed to do so.

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Citations

Nov 24, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Banasri HazraUtpal Sanyal
Jan 24, 2012·Journal of Asian Natural Products Research·Alireza NematollahiChristophe Wiart
Dec 19, 2009·Journal of Experimental Botany·Haviva EilenbergAviah Zilberstein
May 31, 2012·Neurological Research·Xian Nan TangMidori A Yenari
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Jan 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peter Mubanga CheukaKelly Chibale
Oct 31, 2009·Memórias do Instituto Oswaldo Cruz·Barasa M ManiafuTeresa Ayuko Akenga
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Sep 1, 2004·Bioorganic & Medicinal Chemistry·Thuyanh TranTodd P Primm
Jan 11, 2005·The Journal of Pharmacy and Pharmacology·Yaxian DingChung-Ho Chang
Nov 5, 2008·Journal of Cellular Biochemistry·Aamir AhmadFazlul H Sarkar
Oct 13, 2012·Medicinal Research Reviews·Subhash PadhyeFazlul H Sarkar
Jan 5, 2018·Artificial Cells, Nanomedicine, and Biotechnology·S RajalakshmiBothiraja Chellampillai
Sep 16, 2017·Experimental Neurobiology·Jong Youl KimMidori A Yenari
Mar 24, 2018·Inflammopharmacology·Amit Chand GuptaDnyaneshwar U Bawankule
Aug 30, 2019·IBRO Reports·Sumit BaruaJong Eun Lee
Apr 4, 2021·International Journal of Molecular Sciences·Sevinj SultanliKatharina F Kubatzky
May 21, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Rupashree Sen, Mitali Chatterjee

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