Synthesis of polyhydroxylated piperidine and pyrrolidine peptidomimetics via one-pot sequential lactam reduction/Joullié-Ugi reaction

The Journal of Organic Chemistry
Piotr SzcześniakBartłomiej Furman

Abstract

A direct approach to the synthesis of polyhydroxylated piperidine and pyrrolidine peptidomimetics is described. The presented strategy is based on one-pot reduction of sugar-derived lactams with Schwartz's reagent followed by a multicomponent Ugi-Joullié reaction.

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Citations

Apr 14, 2016·Journal of the American Chemical Society·Seiya KataharaNoritaka Chida
May 24, 2016·Organic Letters·Akira KatsuyamaSatoshi Ichikawa
Nov 14, 2015·Organic & Biomolecular Chemistry·Maciej MalinowskiWojciech Sas
Apr 28, 2018·Organic & Biomolecular Chemistry·Takaaki SatoNoritaka Chida
Oct 27, 2018·Organic & Biomolecular Chemistry·Karen de la Vega-HernándezVittorio Pace
Apr 20, 2019·Expert Opinion on Drug Discovery·Stefano GazzottiAlessandra Silvani
Oct 28, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pietro CapurroAndrea Basso
Jan 19, 2020·Biophysics Reviews·Himal Kanti Ganguly, Gautam Basu
Jun 12, 2020·Acta Crystallographica. Section E, Crystallographic Communications·Sofia Dallasta PedrosoEdward R T Tiekink
Jan 7, 2021·Organic & Biomolecular Chemistry·Trichada RatthachagPanuwat Padungros
Feb 2, 2021·Beilstein Journal of Organic Chemistry·Michał Mateusz Więcław, Bartłomiej Furman
Jul 29, 2021·Organic & Biomolecular Chemistry·Piotr Szcześniak, Bartłomiej Furman
May 24, 2019·The Journal of Organic Chemistry·Robin J PrinceBrian T Hopkins
Aug 30, 2017·The Journal of Organic Chemistry·Jian-Feng ZhengPei-Qiang Huang
Jun 24, 2020·ACS Combinatorial Science·Mohammad Taghi NazeriAhmad Shaabani

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