Synthesis of pyrido[1,2-a]indole malonates and amines through aryne annulation.

The Journal of Organic Chemistry
Donald C RognessRichard C Larock

Abstract

Pyrido[1,2-a]indoles are known as medicinally and pharmaceutically important compounds, but there is a lack of efficient methods for their synthesis. We report a convenient and efficient route to these privileged structures starting from easily accessible 2-substituted pyridines and aryne precursors. A small library of compounds has been synthesized utilizing the developed method, affording variously substituted pyrido[1,2-a]indoles in moderate to good yields.

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May 14, 2011·The Journal of Organic Chemistry·Donald C Rogness, Richard C Larock

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Citations

Sep 28, 2012·The Journal of Organic Chemistry·Chun LuRichard C Larock
Nov 13, 2015·Organic Letters·Sravan Kumar AithaganiParvinder Pal Singh
Dec 23, 2016·Angewandte Chemie·Huseyin ErguvenBruce A Arndtsen
Mar 12, 2016·Organic & Biomolecular Chemistry·Sudam Ganpat DawandeSreenivas Katukojvala
Dec 18, 2014·Chemical Communications : Chem Comm·Iyyanar KarthikeyanGovindasamy Sekar
May 8, 2015·Chemical Communications : Chem Comm·Martin PawliczekDaniel B Werz
Nov 8, 2012·Organic & Biomolecular Chemistry·Anton V DubrovskiyRichard C Larock
Jan 29, 2019·Chemical Communications : Chem Comm·Xin HuangBo Peng
Mar 16, 2013·Chemical Communications : Chem Comm·Huawen HuangHuanfeng Jiang
Feb 5, 2021·The Journal of Organic Chemistry·Wei Chuen ChanKazunori Koide
Feb 19, 2021·Chemical Reviews·Jiarong ShiYang Li
Apr 29, 2021·Organic & Biomolecular Chemistry·Yunxin YaoOlivier Provot
Dec 12, 2012·The Journal of Organic Chemistry·Chun LuRichard C Larock
Jul 27, 2012·Organic Letters·Ranjeet A DhokaleSantosh B Mhaske
Aug 16, 2017·The Journal of Organic Chemistry·Bin ChengHongbin Zhai

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