Synthesis of pyrroloindolines and furoindolines via cascade dearomatization of indole derivatives with carbenium ion

Chemical Communications : Chem Comm
Chuan LiuShu-Li You

Abstract

A highly efficient intermolecular cascade dearomatization of substituted indoles with benzodithiolylium tetrafluoroborate has been developed. This reaction provides a novel strategy to synthesise C3 methyl-substituted pyrroloindolines and furoindolines under mild reaction conditions, the utility of which has been demonstrated by the synthesis of esermethol and physovenine in a highly concise manner.

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Citations

Jan 23, 2016·Organic & Biomolecular Chemistry·Sindhura BadigenchalaGovindasamy Sekar
Dec 18, 2015·Organic Letters·Heng ZhangShang-Dong Yang
Nov 5, 2016·The Journal of Organic Chemistry·Ya-Ni WangWen-Jing Xiao
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Sep 26, 2019·Organic & Biomolecular Chemistry·Rodney A Fernandes, Jothi L Nallasivam
Dec 12, 2018·Organic Letters·Xunbo LuFangrui Zhong
Feb 22, 2017·Organic Letters·Valquírio G CorreiaLeandro H Andrade

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