PMID: 7539250Mar 1, 1995Paper

Synthesis of pyrryl aryl sulfones targeted at the HIV-1 reverse transcriptase

Archiv der Pharmazie
M ArticoP La Colla

Abstract

Various aryl 1-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1. 2-Nitrophenyl-2-ethoxycarbonyl-1-pyrryl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitro anti-HIV-1 activity and cytotoxicity of 41 compounds is reported. Some structure-activity relationships are discussed also in comparison with the known NPPS (2-nitrophenyl phenyl sulfone).

References

Mar 17, 1992·Biochemical Pharmacology·E Tramontano, Y C Cheng
Sep 28, 1990·Science·H MitsuyaS Broder
Aug 1, 1988·Journal of Virological Methods·R PauwelsE De Clercq
Mar 6, 1993·Lancet·D J Dodwell

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Citations

Sep 10, 2002·Bioorganic & Medicinal Chemistry Letters·Laura GarutiErik De Clercq
Nov 23, 2013·Future Medicinal Chemistry·Valeria FamigliniRomano Silvestri
Mar 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valeria FamigliniRomano Silvestri
Aug 17, 2010·Antiviral Chemistry & Chemotherapy·Giuseppe La ReginaRomano Silvestri
Dec 3, 2009·Journal of Combinatorial Chemistry·Mahesh M SavantYogesh T Naliapara
Jun 1, 2001·Journal of Medicinal Chemistry·J H ChanD K Stammers
May 30, 2003·Journal of Medicinal Chemistry·Romano SilvestriPaolo La Colla

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