Synthesis of remote fluoroalkylated alkenes by a palladium-catalyzed relay Heck-type reaction

Chemical Communications : Chem Comm
Lixin LiYan-Na Ma

Abstract

Herein, we report a palladium-catalyzed relay Heck-type reaction of fluoroalkyl bromide and terminal alkenes. The reaction involves fluoroalkylation of alkenes and migration of double bonds via a 1,5-hydrogen atom transfer strategy. Through this method, a series of remote fluoroalkylated alkenes was obtained under mild conditions.

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