Synthesis of S-linked NeuAc-α(2-6)-di-LacNAc bearing liposomes for H1N1 influenza virus inhibition assays

Bioorganic & Medicinal Chemistry
Hou-Wen ChengPi-Hui Liang

Abstract

S-NeuAc-α(2-6)-di-LacNAc (5) was efficiently synthesized by a [2+2] followed by a [1+4] glycosylation, and later conjugated with 1,2-dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE) to form both single-layer and multi-layer homogeneous liposomes in the presence of dipalmitoyl phosphatidylcholine (DPPC) and cholesterol. These liposomes were found to be weak inhibitors in both the influenza virus entry assay and the hemagglutination inhibition assay. The single layer liposome was found to more efficiently interfere with the entry of the H1N1 influenza virus into MDCK cells than the multilayer liposome containing 5.

Citations

Sep 4, 2020·ChemPlusChem·Lili LiangGrzegorz Lisak
Feb 2, 2019·Current Medicinal Chemistry·Mário FernandesAndreia C Gomes
Oct 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu-Pu Juang, Pi-Hui Liang
Jun 11, 2020·ACS Nano·Carsten WeissLucia Gemma Delogu

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