Synthesis of saturated long chain fatty acids from sodium acetate-1-C14 by Mycoplasma.

Journal of Bacteriology
J D Pollack, M E Tourtellotte

Abstract

Three strains of Mycoplasma, M. laidlawii A and B, and Mycoplasma sp. A60549, were grown in broth containing sodium acetate-1-C(14). The methyl esters of the phospholipid fatty acids of harvested radioactive cells were prepared and identified by comparison of their mobilities to known radioactive fatty acid methyl esters by use of a modified reversed-phase partition-thin layer chromatographic technique. No radioactive methyl oleate or methyl linoleate was detected. Compounds migrating as radioactive methyl myristate, stearate, palmitate, and, with less certainty, laurate and octanoate were detected. The qualitative findings for all three organisms appeared similar. M. laidlawii B synthesized a radioactive substance, presumably a saturated fatty acid detected as the methyl ester derivative, which migrated in a position intermediate to methyl myristate-1-C(14) and methyl palmitate-1-C(14). This work indicates that M. laidlawii A and B and Mycoplasma sp. A60549 are capable, in a complex medium containing fatty acids, of synthesizing saturated but not unsaturated fatty acids entirely or in part from acetate.

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Citations

Aug 17, 1999·Biochemical and Biophysical Research Communications·A V KukekovaS N Borchsenius
Feb 1, 1973·Journal of Bacteriology·S RottemS Razin
Dec 5, 1967·Biochimica Et Biophysica Acta·J E Cronan
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May 27, 1980·Biochimica Et Biophysica Acta·S Rottem
Jan 1, 1970·Journal of Bacteriology·R N McElhaney, M E Tourtellotte
Feb 5, 1973·Biochemical and Biophysical Research Communications·A Rossi, J W Corcoran
Sep 1, 1970·Infection and Immunity·J D PollackL B Senterfit
Apr 25, 1969·Science·R N McElhaney, M E Tourtellotte

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