Synthesis of sharply thermo and PH responsive PMA-b-PNIPAM-b-PEG-b-PNIPAM-b-PMA by RAFT radical polymerization and its schizophrenic micellization in aqueous solutions

Designed Monomers and Polymers
Lida AhmadkhaniAbolfazl Akbarzadeh

Abstract

Sharply thermo- and pH-responsive pentablock terpolymer with a core-shell-corona structure was prepared by RAFT polymerization of N-isopropylacrylamide and methacrylic acid monomers using PEG-based benzoate-type of RAFT agent. The PEG-based RAFT agent could be easily synthesized by dihydroxyl-capped PEG with 4-cyano-4-(thiobenzoyl) sulfanylpentanoic acids, using esterification reaction. This pentablock terpolymer was characterized by1H NMR, FT-IR, and GPC. The PDI was obtained by GPC, indicating that the molecular weight distribution was narrow and the polymerization was well controlled. The thermo- and pH-responsive micellization of the pentablock terpolymer in aqueous solution was investigated using fluorescence spectroscopy technique, UV-vis transmittance, and TEM. The LCST of pentablock terpolymer increased (over 50 °C) compared to the NIPAM homopolymer (~32 °C), due to the incorporation of the hydrophilic PEG and PMA blocks in pentablock terpolymer (PNIPAM block as the core, PEG the block and the hydrophilic PMA block as the shell and the corona). Also, pH-dependent phase transition behavior shows at a pH value of about ~5.8, according to pKa of MAA. Thus, in acidic solution at room temperature, the pentablock terpolymer se...Continue Reading

References

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Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eun Seong LeeYou Han Bae
Jan 23, 2010·Nature Materials·Martien A Cohen StuartSergiy Minko
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Nov 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoye GaoXuesi Chen

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Citations

Jul 24, 2018·Journal of Biomaterials Science. Polymer Edition·Somayyeh Fallah Iri SoflaMortaza Mirzaei
Oct 3, 2020·Biomaterials Science·Mahsa ShahriariMona Alibolandi
Dec 20, 2020·International Journal of Biological Macromolecules·Aliyeh GhamkhariMichael R Hamblin
Feb 15, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Yeonju ParkYoung Mee Jung

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Methods Mentioned

BETA
scanning
transmission
PMA
scanning electron microscopy
column chromatography
Fluorescence
Transmission electron microscopy
in

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