Synthesis of single-enantiomer bioactive molecules: a brief overview

Chirality
Abdul Rouf, S C Taneja

Abstract

Chiral-center enantiomers have been shown to differ significantly in biological activity, pharmacodynamics, pharmacokinetics and toxicity. New developments in the stereoselective organic synthesis have enriched the vast literature of synthetic methodologies applicable to access natural products as well as bioactive molecules. These compounds also include new drugs, drug candidates and reagents used to explore biological processes. The article reviews the synthesis of optically pure drugs, biologically active intermediates and amino alcohols by using different methods.

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Citations

Jul 15, 2015·Organic & Biomolecular Chemistry·Brian LeónRoger G Linington
Mar 22, 2015·Biotechnology Advances·Amanda S de MirandaRodrigo O M A de Souza
Oct 30, 2016·Chirality·Zhao-Hong HuWei-Jian Wu
Oct 4, 2017·Expert Opinion on Drug Discovery·Daniela RossiSimona Collina
Jul 28, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seung-Mann PaekHwayoung Yun
May 3, 2018·Chemical Science·Nastaran Salehi MarzijaraniBabak Borhan
Aug 12, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nuno A L PereiraMaria M M Santos

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