PMID: 6109026Nov 1, 1980Paper

Synthesis of some 5-phenylhexahydroazepino[4,5-b]indoles as potential neuroleptic agents

Journal of Medicinal Chemistry
A J ElliottH Guzik

Abstract

5-Phenyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole (3a) and five derivatives have been prepared and screened for neuroleptic activity. None of the compounds antagonized methamphetamine aggregate toxicity in mice. A number of compounds, including 3a and its 3-methyl derivative 3d, showed activity in the antidepressant screens.

Citations

Oct 20, 2000·Archiv der Pharmazie·J KraxnerP Gmeiner

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