PMID: 2505275Apr 1, 1989Paper

Synthesis of some heterocycles of pharmaceutical interest

Die Pharmazie
M A MetwallyA M Khalil

Abstract

The condensation of 2-aminobenzimidazole (2), 3-amino-1,2,4-triazole (3), 5-aminotetrazole (4), 1-phenyl-3-aminopyrazolone (5), 2-aminobenzothiazole (6) and 2-amino-5-ethylthiadiazole (7) with 3-aryl-2,4-dicarboethoxy-5-hydroxy-5-methylcyclohexanones (1) has been investigated. Oxazepines 19 and 21 has been obtained from 1 and o-aminophenol. Cyclization of the carboxanilides 22 with polyphosphoric acid (PPA) gave the phenanthridinecarboxylates 23, while the cyclization of the arylhydrazones 26 gave the cinnoline carboxylate 27. The structures of the hitherto unknown ring systems have been confirmed by analytical and spectral methods. Some of the synthesized compounds were screened to test their antimicrobial and antifungal properties.

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Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.