Synthesis of some new pyridine-2,6-carboxamide-derived Schiff bases as potential antimicrobial agents.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Mohamed A Al-Omar, Abd El-Galil E Amr

Abstract

A series of pyridine-bridged 2,6-bis-carboxamide Schiff's bases has been prepared starting from 2,6-pyridinedicarbonyl dichloride (1) and L-alanine or 2-methyl-alanine methyl ester.The coupling of acid chloride 1 with L-alanine methyl ester hydrochloride -or 2-methylalanine methyl ester hydrochloride gave the corresponding 2,6-bis-carboxamide pyridine methyl esters 2a,b.Hydrazonolysis of 2 with hydrazine hydrate afforded the corresponding bis-hydrazides 3a,b. Treatment of 3a,b with appropriate aromatic or heterocyclic aldehydes afforded the corresponding pyridine- bridged 2,6-bis-carboxamide Schiff's bases 4a-f and 5a-f, respectively. The newly synthesized compounds 2-5 were screened for their bactericidal and fungicidal activities. Many of the obtained compounds exhibited significant antimicrobial activity, comparable to streptomycin and fusidic acid, which were used as reference antibiotic drugs.

References

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Citations

May 17, 2012·Acta Crystallographica. Section E, Structure Reports Online·Mohamed A Al-OmarHoong-Kun Fun
Jun 16, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Serkan DemirMüberra Andac
Jan 13, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Temitope E OlalekanGareth M Watkins
Nov 21, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aisha S M HossanAbd El-Galil E Amr
Dec 12, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Osama I Abd El-SalamAbd El-Galil E Amr
Sep 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rashad A Al-SalahiAbd El-Galil E Amr
Mar 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohamed El-NaggarMohamed A Al-Omar
Mar 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohamed H Abo-GhaliaAhmed H Bakheit
Sep 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abd El-Galil E AmrElsayed A Elsayed
Jan 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abd El-Galil E AmrMohamed M Abdallah
Feb 15, 2019·Mini Reviews in Medicinal Chemistry·Abd El-Galil E AmrHazem A Ghabbour

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