Abstract
A new series of pyrazole, bipyridine, N-amide derivatives and Schiff bases was synthesized using compound 2-(3-cyano-6- (thiophen-2-yl)-4,4'- bipyridin-2-yloxy) acetohydrazide (3) as a starting material. The compounds structures were confirmed depending on the spectroscopic methods and elemental analysis. Also, the compounds were evaluated as anticancer agents by the compounds screened towards adenocarcinoma breast cancer cell line (MCF-7). The compounds showed a promising cytotoxic effect against human breast cancer cells. Compound 7c showed the most effective activity compared to other compounds with (IC50 = 0.6 ± 0.01 μg mL-1) in comparison with the reference drug doxorubicin (IC50 = 1.6 ± 0.02 μg mL-1). While compound 3 is closely active with doxorubicin. Also compounds 2, 4, 6, 7a, 7b and 7d showed noticeable cytotoxic effect. Early and late apoptotic cells were detected using Acridine orange/Ethidium bromide staining technique. The results of biologically screening of the tested compounds give an idea about the importance in the compounds acting against breast cancer and may lead to the discovery of a potent anticancer agent.
References
Feb 1, 1974·Journal of Medicinal Chemistry·F A FrenchR W Brockman
Nov 1, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Bonte
Aug 21, 2002·Anti-cancer Drugs·B-M FrostE Lindhagen
Jul 5, 2003·Chemical & Pharmaceutical Bulletin·Ashraf Hassan AbadiGhaneya Sayed Hassan
Oct 20, 2006·Natural Product Research·Ibrahim BouabdallahAhmed Melhaoui
Sep 11, 2007·Bioorganic & Medicinal Chemistry Letters·Madhavi PannalaJie-Fei Cheng
Jan 9, 2010·Bioorganic & Medicinal Chemistry Letters·Sumesh EswaranImran H Chowdhury
Mar 9, 2010·Mini Reviews in Medicinal Chemistry·E-Hu LiuPing Li
Nov 26, 2010·European Journal of Medicinal Chemistry·Mansour S Al-SaidMostafa M Ghorab
Sep 3, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Ali Mokhtar MahmoudHany A El-Shemy
Feb 5, 2013·International Journal of Biological Macromolecules·Magdy Y AbdelaalHossa F Al-Shareef
Jun 11, 2016·Fitoterapia·Sabrin R M IbrahimSamir A Ross
Jul 8, 2016·SpringerPlus·Hossa F Al-ShareefEssam M Hussein
Mar 6, 2017·Critical Reviews in Oncology/hematology·Kate RobertsNatasha Woodward
Aug 5, 2017·Chemical & Pharmaceutical Bulletin·Hossa Fahad AlshareefAbdellatif Mohamed Salaheldin
Apr 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdulrahman M AlahdalSameh S Elhady
Sep 27, 2019·European Journal of Medicinal Chemistry·Sanjay KumarInder Pal Singh