Synthesis of Spiropentadiene Pyrazolones by Rh(III)-Catalyzed Formal sp3 C-H Activation/Annulation

Organic Letters
Jiuan ZhengHequan Yao

Abstract

A Rh-catalyzed enol-directed formal sp3 C-H activation/annulation of α-arylidene pyrazolones with alkynes has been developed. This reaction provides a convenient route to synthesize spiropentadiene pyrazolones in good to excellent yields at room temperature, exhibiting good functional group tolerance, gram scalability, and high regioselectivity. Of note, the α-arylidene pyrazolone was introduced as a novel C3 synthon in C-H activation/annulation.

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Citations

Apr 11, 2018·Organic & Biomolecular Chemistry·Xueli WangLixin Xia
Apr 25, 2018·Chemistry : a European Journal·Yang Li, Silong Xu
Sep 19, 2018·Chemical Communications : Chem Comm·Siyuan LiuBaomin Wang
Mar 2, 2019·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Xin XieBo Han

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