PMID: 423119Mar 1, 1979Paper

Synthesis of substituted 2-aminopyrrole analogs of lidocaine I

Journal of Pharmaceutical Sciences
R W JohnsonJ W Sowell

Abstract

The synthesis, local anesthetic, and antiarrhythmic properties of nine 2-diethylaminoacetamido-3-cyano-4-methyl-5-substituted pyrroles are described. All compounds showed local anesthetic activity by the guinea pig wheal test and antiarrhythmic activity for chloroform-induced ventricular arrhythmias in mice.

Citations

Nov 1, 1982·Clinical and Experimental Pharmacology & Physiology·Y L ChiangJ W Kosh
Aug 1, 1979·Journal of Pharmaceutical Sciences·R W JohnsonJ W Sowell

Related Concepts

Topical anesthetic
Cardiac Depressants
Cavia porcellus
Lidocaine Monohydrochloride, Monohydrate
Pyrroles

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