PMID: 480174Aug 1, 1979Paper

Synthesis of substituted 2-aminopyrrole analogs of lidocaine II

Journal of Pharmaceutical Sciences
R W JohnsonJ W Sowell


The synthesis and local anesthetic and antiarrhythmic properties of eight substituted 2-diethylaminoacetamido-3-carbamyl-4-methylpyrroles are described. Three compounds showed significant local anesthetic activity by the guinea pig wheal test, and four showed antiarrhythmic activity against chloroform-induced ventricular arrhythmias in mice.


Mar 1, 1979·Journal of Pharmaceutical Sciences·R W JohnsonJ W Sowell


Nov 1, 1982·Clinical and Experimental Pharmacology & Physiology·Y L ChiangJ W Kosh

Related Concepts

Topical anesthetic
Cardiac Depressants
Atrial Fibrillation
Cavia porcellus
Lidocaine Monohydrochloride, Monohydrate
Structure-Activity Relationship

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