PMID: 480174Aug 1, 1979Paper

Synthesis of substituted 2-aminopyrrole analogs of lidocaine II

Journal of Pharmaceutical Sciences
R W JohnsonJ W Sowell

Abstract

The synthesis and local anesthetic and antiarrhythmic properties of eight substituted 2-diethylaminoacetamido-3-carbamyl-4-methylpyrroles are described. Three compounds showed significant local anesthetic activity by the guinea pig wheal test, and four showed antiarrhythmic activity against chloroform-induced ventricular arrhythmias in mice.

References

Mar 1, 1979·Journal of Pharmaceutical Sciences·R W JohnsonJ W Sowell

Citations

Nov 1, 1982·Clinical and Experimental Pharmacology & Physiology·Y L ChiangJ W Kosh

Related Concepts

Topical anesthetic
Cardiac Depressants
Atrial Fibrillation
Cavia porcellus
Lidocaine Monohydrochloride, Monohydrate
Pyrroles
Structure-Activity Relationship

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.