PMID: 20636268Jul 20, 2010Paper

Synthesis of sulfated pectins and their anticoagulant activity

Biochemistry. Biokhimii︠a︡
F V VityazevYu S Ovodov

Abstract

The following pectins were sulfated: bergenan BC (the pectin of Bergenia crassifolia L), lemnan LM (the pectin of Lemna minor L), and galacturonan as a backbone of pectins. Pyridine monomethyl sulfate, pyridine sulfotrioxide, and chlorosulfonic acid were used as reagents for sulfation. Chlorosulfonic acid proved to be the optimal reagent for sulfation of galacturonan and other pectins. Galacturonan and pectin derivatives with different degrees of sulfation were synthesized and their anticoagulant activities were shown to depend on the quantity of sulfate groups in the pectin macromolecules.

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Citations

May 7, 2014·Critical Reviews in Food Science and Nutrition·Jun ChenShun-Jing Luo
Sep 25, 2012·Bioorganicheskaia khimiia·F V VitiazevV V Golovchenko
Jun 21, 2020·Fitoterapia·Oksana ZaitsevaTatyana Polezhaeva

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