PMID: 3761326Oct 1, 1986Paper

Synthesis of sulfur analogues of alkyl lysophospholipid and neoplastic cell growth inhibitory properties

Journal of Medicinal Chemistry
S L Morris-NatschkeC Piantadosi

Abstract

Five sulfur-containing phospholipid analogues (compounds 1-5) of alkyl lysophospholipid (1-O-alkyl-2-O-methyl-rac-glycero-3-phosphocholine, ALP) were synthesized and tested for inhibition of neoplastic cell proliferation with two human ovarian carcinoma cell lines in a clonogenic assay and with the HL-60 promyelocytic leukemia cell line. Compared with 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OMe), the most active reference analogue, these thio analogues are at least as active against HL-60 cells, and the 1-S-hexadecyl-2-O-ethyl analogue (2) is twice as active in the clonogenic assays.

Citations

May 1, 1995·Medicinal Research Reviews·W J HoulihanS H Cheon
Nov 1, 1987·Lipids·H K Mangold, N Weber
Nov 1, 1987·Lipids·A NosedaE J Modest
Nov 3, 1988·Biochimica Et Biophysica Acta·A NosedaE J Modest
Aug 1, 1990·Chemistry and Physics of Lipids·J M ZeidlerH J Roth
Jan 1, 1992·Drug Metabolism Reviews·S Garattini
Jan 1, 1988·Cancer Investigation·C P Burns
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Jul 1, 2015·Chemical Science·Cun Yu ZhouNeal Krishna Devaraj
Mar 10, 2021·Organic & Biomolecular Chemistry·Charlotte M SevrainPaul-Alain Jaffrès
Nov 18, 2004·Bioorganic & Medicinal Chemistry Letters·Yusuo ChangAdrian L Schwan
Feb 29, 1988·Biochemical and Biophysical Research Communications·L W DanielC Piantadosi

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