Synthesis of symmetrical bis-alkynyl or alkyl pyridine and thiophene derivatives and their antiangiogenic activities

Bioorganic & Medicinal Chemistry Letters
Chan Mug AhnHyean-Woo Lee

Abstract

Fourteen symmetrical bis-alkynyl pyridine and thiophene derivatives were synthesized and their antiangiogenic activity was evaluated with the proliferation and tube formation inhibitory activity on the human umbilical vein endothelial cells (HUVEC). Compounds 6, 8, and 10, rigid mimetic structure of curcumin, showed the potent growth inhibitory activity and the potent tube formation inhibitory activity.

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Citations

Sep 8, 2010·Chemical Society Reviews·Calden N CarrollDarren W Johnson
Dec 23, 2009·Medicinal Research Reviews·Dinesh Kumar Agrawal, Pushpesh Kumar Mishra
Dec 13, 2005·Bioorganic & Medicinal Chemistry·Waylon M WeberDavid L Vander Jagt
Sep 9, 2008·Biochemical Pharmacology·Preetha AnandBharat B Aggarwal
Jan 31, 2009·Bioorganic & Medicinal Chemistry Letters·Chan Mug AhnSeokjoon Lee
Jul 5, 2005·Bioorganic & Medicinal Chemistry Letters·Ho Bum WooChan Mug Ahn
Jan 8, 2015·Chemical Communications : Chem Comm·Eleni VasilikogiannakiManolis Stratakis
Feb 22, 2011·Organic & Biomolecular Chemistry·Wenjun LiJinxing Ye
Apr 1, 2012·Chemical Science·Jeffrey M EngleMichael M Haley
May 3, 2005·Bioorganic & Medicinal Chemistry·Waylon M WeberDavid L Vander Jagt

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