Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum.

Beilstein Journal of Organic Chemistry
Friederike I NollmannHelge B Bode

Abstract

The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from the efficient synthesis enabled additional bioactivity tests leading to the identification of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria.

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Citations

Oct 3, 2012·Journal of Natural Products·Qiuqin ZhouHelge B Bode
Oct 15, 2013·International Journal of Medical Microbiology : IJMM·Sacha J PidotChristian Hertweck
Nov 10, 2013·Chemistry : a European Journal·Qiuqin ZhouHelge B Bode
Oct 30, 2014·Chemistry : a European Journal·Max KronenwerthHelge B Bode
Apr 22, 2015·Natural Product Reports·Laura V FlórezMartin Kaltenpoth
Oct 29, 2015·Annals of the New York Academy of Sciences·Victoria L Challinor, Helge B Bode
Oct 16, 2019·Nature Microbiology·Gaoyan WangYasuo Yoshikuni
Sep 24, 2019·Natural Product Reports·Raúl G Saraiva, George Dimopoulos
Jul 4, 2018·Biotechnology Letters·Yun XuePing Li
Aug 28, 2020·Probiotics and Antimicrobial Proteins·E Booysen, L M T Dicks
Jan 9, 2019·Frontiers in Microbiology·Jönike DreyerLeon M T Dicks
Jul 8, 2019·Experimental Parasitology·Ana Maria AntonelloPedro Roosevelt Torres Romão

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Methods Mentioned

BETA
NMR
FCS

Software Mentioned

R
Softmax
IN Cell Analyzer 1000 Workstation

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