Synthesis of temperature/pH dual-sensitive supramolecular micelles from β-cyclodextrin-poly(N-isopropylacrylamide) star polymer for drug delivery

Colloids and Surfaces. B, Biointerfaces
Zaishuai ZhouXunyong Liu

Abstract

In this paper, temperature and pH dual-sensitive supramolecular micelles were constructed from star polymer β-cyclodextrin-poly(N-isopropylacrylamide) (β-CD-PNIPAM) and benzimidazole terminated poly(ε-caprolactone) (BM-PCL). The supramolecular micelles were formed based on the reversible host-guest recognition between β-CD and BM. The size of supramolecular micelles was about 50-100 nm and the LCST was about 30.5 ℃. The drug loading efficiency of supramolecular micelles for DOX was high due to the hydrophobic micelles core of PCL and hydrophobic cavity of β-CD. The release of drugs from supramolecular micelles was suppressed at neutral solution and room temperature but accelerated at acidic solution and 37 ℃. The drug loaded supramolecular micelles exhibited higher anti-cancer activity than free drugs. These temperature and pH dual-sensitive supramolecular micelles might possess potential applications for anticancer drug delivery.

Citations

May 26, 2021·Drug Development and Industrial Pharmacy·Na QiuGuangxi Zhai
Oct 5, 2021·Journal of Biomaterials Science. Polymer Edition·Xiao HanGuoquan Zhang
Nov 5, 2020·Carbohydrate Polymers·Bingren TianJiayue Liu

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