Synthesis of tetracyclic pyrido-fused dibenzodiazepines via a catalyst-free cascade reaction.

Molecular Diversity
Abdolali Alizadeh, Akram Bagherinejad

Abstract

An efficient, eco-friendly protocol has been described for the chemoselective synthesis of tetracyclic pyrido-fused dibenzodiazepines derivatives via catalyst-free, three-component reaction of dimedone, 1,2-diamines, 3-formylchromones, and malononitrile. The significant advantages of this cascade approach are to create two new rings and four new σ bonds containing three C-N and one C-C bond, as well as the breakdown of a C-O bond.

References

Jan 1, 1966·Journal of Medicinal Chemistry·P M Carabateas, L S Harris
Feb 24, 2007·Bioorganic & Medicinal Chemistry Letters·Jennifer DourlatChristiane Garbay
Jan 29, 2008·European Journal of Medicinal Chemistry·Braulio InsuastyJusto Cobo
Apr 4, 2009·Bioorganic & Medicinal Chemistry Letters·David McGowanPierre Raboisson
Jun 26, 2009·Bioorganic & Medicinal Chemistry Letters·Jiasheng FuPeter Coward
Apr 7, 2012·The Journal of Organic Chemistry·Abdolali AlizadehLong-Guan Zhu
Oct 12, 2012·Journal of Medicinal Chemistry·Jiří SchimerJan Konvalinka

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