Synthesis of the Trypanosoma cruzi LPPG heptasaccharyl myo-inositol

Journal of the American Chemical Society
Markus Hederos, Peter Konradsson

Abstract

Synthesis of the heptasaccharyl myo-inositol found in Trypanosoma cruzi lipopeptidophosphoglycan was accomplished using a convergent assembly of three building blocks. The target compound is the first complete 2-aminoethyl phosphonic acid substituted glycan related to the glycosylphosphatidylinositol anchor family to be synthesized. The order of assembly enables synthesis of phosphoinositol oligosaccharides related to other glycosylinositolphospholipids in Tr. cruzi, the protozoan parasite causing Chagas' disease, which is endemic in South America.

Citations

Mar 31, 2011·Natural Product Reports·Andrei V Nikolaev, Nawaf Al-Maharik
Dec 14, 2011·Chemical Science·Benjamin M Swarts, Zhongwu Guo
Aug 10, 2019·Journal of Carbohydrate Chemistry·Shuai MengJianglong Zhu
Oct 31, 2006·Bioorganic & Medicinal Chemistry Letters·Gérald LopezCaroline Nugier-Chauvin
Oct 24, 2006·Carbohydrate Research·Ronan EuzenDaniel Plusquellec
Apr 29, 2008·Carbohydrate Research·Pauline PeltierVincent Ferrières
Jan 2, 2010·Carbohydrate Research·Verónica M MendozaCarola Gallo-Rodriguez

❮ Previous
Next ❯