Synthesis of theranostic epithelial cell adhesion molecule targeted mesoporous silica nanoparticle with gold gatekeeper for hepatocellular carcinoma

Nanomedicine
Maryam BabaeiMona Alibolandi

Abstract

In this study, we report the fabrication of epithelial cell adhesion molecule targeted 5-fluorouracil (5-FU) encapsulated PEGylated mesoporous silica nanoparticles (NPs) hybridized with gold NPs (PEG-Au@Si-5-FU) as gatekeeper for theranostic applications. The prepared targeted and nontargeted formulations were evaluated in vitro in terms of their cellular internalization and toxicity. The prepared theranostic hybrid system was also implemented for computed tomography of HepG2 tumor-bearing nude mice in vivo. Fluorescence microscopy and MTT assay demonstrated that the developed epithelial cell adhesion molecule-PEG-Au@Si-5-FU had higher cytotoxicity than nontargeted PEG-Au@Si-5-FU in 2D and 3D HepG2 cell cultures. Moreover, the targeted hybrid system was preferentially accumulated in HepG2 tumor cells in vitro and in vivo. This work introduces a novel strategy for developing multimodal NPs via nanoparticulate hybrid materials.

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Citations

Jul 25, 2017·Nanomaterials·Anna Watermann, Juergen Brieger
Mar 23, 2019·Expert Opinion on Drug Delivery·Rafael R CastilloMaría Vallet-Regí
Jun 30, 2019·Pharmaceutics·Thashini Moodley, Moganavelli Singh
Dec 17, 2019·Therapeutic Delivery·Katherine E Redd BowmanCarol S Lim
Aug 21, 2020·Journal of Drug Targeting·Mohsen GhaferiSeyed Ebrahim Alavi
Jul 26, 2019·World Journal of Gastroenterology : WJG·Guo-Qing ZhangYong-Xiang Zhao
May 14, 2020·Nanomaterials·Miguel Gisbert-Garzarán, María Vallet-Regí
Jun 12, 2020·Pharmaceutics·Sugata Barui, Valentina Cauda
Jul 2, 2019·International Journal of Pharmaceutics·Marimuthu CitartanThean-Hock Tang
Jan 12, 2021·Biomaterials Science·Monireh FalsafiMona Alibolandi
Jan 16, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Elnaz BagheriMohammad Ramezani
Jan 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Candace M DaySanjay Garg
Dec 24, 2020·International Journal of Molecular Sciences·Miguel Gisbert-GarzaránMaría Vallet-Regí
Nov 7, 2020·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Seyed Mojtaba Mashmoul MoghadamMohammad Ramezani

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Methods Mentioned

BETA
surgical resection
by surgical
infrared spectroscopy
scanning
x-ray spectroscopy
fluorescence microscopy
Transmission electron microscopy
Scanning electron microscopy
flow cytometry

Software Mentioned

MicroSynth
WinDMI

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