Synthesis of thiadiazole derivatives bearing hydrazone moieties and evaluation of their pharmacological effects on anxiety, depression, and nociception parameters in mice

Archives of Pharmacal Research
Ozgür Devrim CanZafer Asim Kaplancikli

Abstract

Novel thiadiazole derivatives bearing hydrazone moieties were synthesized through the reaction of 2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio)]acetohydrazide with aldehydes/ketones. The chemical structures of the compounds were elucidated by (1)H-NMR, (13)C-NMR, MS-FAB spectral data, and elemental analyses. Behavioral effects of the test compounds in mice were examined by hole-board, activity cage, tail suspension and modified forced swimming tests (MFST). Antinociceptive activities were evaluated using the hot-plate and tail-clip methods. Results of the experiments indicated that the test compounds did not significantly change the exploratory behaviors or locomotor activities of animals in the hole-board and activity cage tests, respectively. Administration of the reference drug fluoxetine (10 mg/kg) and compounds 3a, 3b, 3c, 3j, 3k, and 3l significantly shortened the immobility times of animals in the tail suspension and MFST tests, indicating the antidepressant-like effects of these derivatives. Morphine (10 mg/kg) and compounds 3a, 3b, 3c, 3d, 3e, 3j, 3k, and 3l increased the reaction times of mice in both the hot-plate and tail-clip tests, indicating the antinociceptive effects of these compounds. To the best of our knowledge,...Continue Reading

References

Nov 1, 1986·Journal of Medicinal Chemistry·C B ChapleoA P Welbourn
Nov 1, 1986·Journal of Medicinal Chemistry·M R StillingsD S Walter
Aug 1, 1994·Anesthesia and Analgesia·C H WongV K Zbuzek
Feb 11, 2000·Il Farmaco·E E ChufánL Bruno-Blanch
Mar 15, 2000·The Journal of Pharmacy and Pharmacology·R Bruns, P Rohdewald
Dec 19, 1996·Chemical Reviews·George A. Patani, Edmond J. LaVoie
May 15, 2002·Trends in Pharmacological Sciences·John F CryanIrwin Lucki
May 26, 2004·Bioorganic & Medicinal Chemistry·Gildásio A SilvaCarlos A M Fraga
Jan 11, 2005·Current Medicinal Chemistry·Lídia Moreira Lima, Eliezer J Barreiro
Oct 3, 2006·European Journal of Medicinal Chemistry·Jegadeesan Vaigunda RagavendranPerumal Yogeeswari
Oct 26, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sevim Rollas, S Güniz Küçükgüzel
Oct 1, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Ahmet OzdemirYağmur Tunali
Oct 17, 2008·European Journal of Medicinal Chemistry·Zafer Asim KaplancikliPierre Chevallet
Sep 29, 2009·Archives of Pharmacal Research·Ozgür Devrim CanYusuf Oztürk
Jul 1, 2010·European Journal of Medicinal Chemistry·Zafer Asim KaplancikliOzgür Devrim Can
Aug 3, 2010·Pharmaceutical Biology·Ozgür Devrim CanYusuf Oztürk
Mar 19, 2011·Journal of Clinical Pharmacology·Pinky DharmshaktuBhupinder Singh Kalra
Apr 5, 2011·Natural Product Research·Ozgür Devrim CanFilippo Maggi
Jul 16, 2011·European Journal of Pharmacology·Natasha Frasson PavinLucielli Savegnago

❮ Previous
Next ❯

Citations

Jun 4, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yanis Toledano-MagañaBlanca M Cabrera-Vivas
Sep 4, 2016·Life Sciences·Merve Kasap, Özgür Devrim Can
Jan 13, 2018·Journal of Biochemical and Molecular Toxicology·Ebru AkkemikZekai Onbasioglu
Mar 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nafiz Öncü CanÜmide Demir Özkay
Aug 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mehlika Dilek AltıntopZafer Asım Kaplancıklı

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Acta Crystallographica. Section E, Structure Reports Online
Chaveng Pakawatchai, Saowanit Saithong
Acta Crystallographica. Section E, Structure Reports Online
Hoong-Kun FunB Kalluraya
Journal of Enzyme Inhibition and Medicinal Chemistry
Zafer Asim KaplancikliOzgür Devrim Can
© 2021 Meta ULC. All rights reserved