Synthesis of three N-nitroso dipeptides N-terminal in proline and a method for their determination in food

Food Additives and Contaminants
A R TrickerD J McWeeny

Abstract

The terminal N-nitroso derivatives of L-prolyl-L-alanine, L-prolylglycine and L-prolyl-4-hydroxy-L-proline have been synthesized and characterized. A procedure suitable for their analysis in biological samples has been developed and is based on the preparation of an aqueous extract, extraction into an organic solvent, separation by high-performance liquid chromatography and detection by a chemiluminescence method. The average recovery in all cases was above 69% at the level of 200 micrograms/kg using cured meat as a food matrix; the detection limit was 10 micrograms/kg.

References

Feb 1, 1974·Nature·M E KnowlesM Thorogood
Jan 1, 1967·Advances in Cancer Research·P N Magee, J M Barnes
Nov 1, 1970·Tetrahedron·W LijinskyJ Loo
Jul 1, 1984·Food Additives and Contaminants·A R TrickerD J McWeeny
Apr 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M J DennisD J McWeeny

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Citations

Oct 1, 1985·Food Additives and Contaminants·A R TrickerD J McWeeny
Jan 1, 1992·Food Additives and Contaminants·A R Tricker, S J Kubacki
Apr 1, 1986·Food Additives and Contaminants·A R TrickerD J McWeeny

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