Synthesis of toll-like receptor-2 targeting lipopeptides as self-adjuvanting vaccines

Methods in Molecular Biology
Brendon Y ChuaDavid C Jackson

Abstract

Effective Th1- and Th2-type immune responses that result in protective immunity against pathogens can be induced by self-adjuvanting lipopeptides containing the lipid moiety dipalmitoyl-S-glyceryl cysteine (Pam2Cys). The potent immunogenicity of these lipopeptides is due to their ability to activate dendritic cells by targeting and signaling through Toll-like receptor-2 (TLR-2). In addition, the simplicity and flexibility in their design as well as their ease of chemical definition and characterisation makes them highly attractive vaccine candidates for humans and animals. We describe in this chapter the techniques involved in the synthesis of an immunocontraceptive lipopeptide vaccine as well as the experimental assays carried out to evaluate its efficiency.

Citations

Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Simona GalloriniAndreas Wack
Nov 20, 2012·Indian Journal of Human Genetics·Vandana D PradhanKanjaksha Ghosh
Feb 3, 2015·Current Protocols in Microbiology·Peter Michael Moyle
May 19, 2010·Expert Review of Respiratory Medicine·Nicole La GrutaStephen J Turner
Jan 15, 2013·ChemMedChem·Peter Michael Moyle, Istvan Toth
Nov 1, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alice E DentonStephen J Turner
Apr 4, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tania CukalacNicole L La Gruta
Apr 25, 2017·Clinical & Translational Immunology·Thi Ho NguyenKatherine Kedzierska
Mar 1, 2016·Chemical Science·Waleed M HusseinMariusz Skwarczynski
Jul 7, 2021·Bioconjugate Chemistry·Ian W Hamley

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