Synthesis of trifluoromethylthioesters from aldehydes via a visible light-promoted radical process

Organic & Biomolecular Chemistry
Meng-Yue WangYong-Qiang Wang

Abstract

We report herein an efficient, economical, and scalable trifluoromethylthiolation of aldehydes to generate trifluoromethylthioesters via a visible light-promoted radical process. The transformation features cheap reagents, simple operation, a broad substrate scope, and especially no metal involved in the reaction. Trifluoromethylthiolations of several complex aldehyde-containing bioactive compounds have been realized; thus the approach has the potential to be an important tool for the late-stage functionalization of advanced synthetic intermediates and bioactive molecules, and should have many applications in medicinal chemistry.

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Citations

Jul 15, 2021·Organic Letters·Tobias E SchirmerBurkhard König
Aug 14, 2021·Chemical Reviews·Xue-Qiang ChuChao-Jun Li

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Methods Mentioned

BETA
irradiating
X-ray
nuclear magnetic resonance
nuclear
NMR

Software Mentioned

SHELXTL

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