Synthesis of trisaccharide repeating unit of fucosylated chondroitin sulfate

Organic & Biomolecular Chemistry
Haiqing HeHong-Bo Qin

Abstract

We described the chemical synthesis of a sulfated trisaccharide repeating unit of fucosylated chondroitin sulfate (FCS), which has significant anticoagulant activity. Well-functionalized monosaccharides were readily prepared, and highly efficient glycosylations using a common activator (NIS/TfOH) were also presented. The synthesized trisaccharide 4 could be used to extend oligosaccharide sequences.

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Citations

Sep 2, 2020·Organic & Biomolecular Chemistry·Cian Mc Carthy, Xiangming Zhu
Jun 5, 2020·Marine Drugs·Giulia VessellaEmiliano Bedini
Jun 23, 2020·The Journal of Organic Chemistry·Liangzhong ZhangBiao Yu
Oct 15, 2020·Journal of the American Chemical Society·Jason S HokiFrank C Schroeder
Nov 26, 2021·Frontiers in Molecular Biosciences·Anshupriya Si, Steven J Sucheck

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Methods Mentioned

BETA
FCS
glycosylation
acetylation

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