Synthesis of unsymmetrical tweezer receptor libraries and identification of receptors for lys-D-ala-D-ala in aqueous solution

Chemistry : a European Journal
Jon ShepherdJeremy D Kilburn

Abstract

Libraries of "unsymmetrical" tweezer receptors, featuring a guanidinium head group as a carboxylate binding site and two independently synthesized peptidic arms, have been prepared and screened to identify receptors for the N-Ac-Lys-D-Ala-D-Ala tripeptide sequence. The binding properties of one such receptor structure, with dye-labeled N-Ac-Lys-D-Ala-D-Ala, were investigated. These studies demonstrated that when attached to the solid-phase, the receptor binds dye-labeled N-Ac-Lys-D-Ala-D-Ala, in buffered aqueous media, with mM binding affinity.

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Jul 15, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Heike Betat, Mario Mörl
Sep 14, 2006·Chemistry : a European Journal·Carsten SchmuckWolfgang Wienand
Mar 21, 2007·Angewandte Chemie·Gennady V OshovskyWillem Verboom
May 24, 2007·Organic & Biomolecular Chemistry·Richard J FitzmauriceJeremy D Kilburn
Jun 15, 2007·Chemistry : a European Journal·Carsten SchmuckThomas Schrader
Jul 20, 2007·Organic & Biomolecular Chemistry·Carsten Schmuck, Laura Hernandez-Folgado
May 9, 2008·Chemical Communications : Chem Comm·Mikhail V RekharskyYoshihisa Inoue
Sep 22, 2010·Chemistry : a European Journal·Muhammad Irfan AshiqJeremy D Kilburn
Jan 27, 2009·Chemical Society Reviews·Stefan Kubik

Related Concepts

Lysyl-alanyl-alanine
Oligopeptides
Structure-Activity Relationship
Combinatorial Chemistry Techniques

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