Synthesis of unsymmetrical tweezer receptor libraries and identification of receptors for lys-D-ala-D-ala in aqueous solution

Chemistry : a European Journal
Jon ShepherdJeremy D Kilburn


Libraries of "unsymmetrical" tweezer receptors, featuring a guanidinium head group as a carboxylate binding site and two independently synthesized peptidic arms, have been prepared and screened to identify receptors for the N-Ac-Lys-D-Ala-D-Ala tripeptide sequence. The binding properties of one such receptor structure, with dye-labeled N-Ac-Lys-D-Ala-D-Ala, were investigated. These studies demonstrated that when attached to the solid-phase, the receptor binds dye-labeled N-Ac-Lys-D-Ala-D-Ala, in buffered aqueous media, with mM binding affinity.


Aug 21, 1992·Science·H C Neu
Mar 1, 1967·European Journal of Biochemistry·P Edman, G Begg
Dec 1, 1996·Natural Product Reports·D H Williams
Jun 9, 1999·Current Opinion in Chemical Biology·B Linton, A D Hamilton
Jun 19, 2001·Chemistry : a European Journal·Tobias M BraxmeierJeremy D Kilburn
Jun 20, 2001·Bioorganic & Medicinal Chemistry Letters·M C MonneeR M Liskamp
Dec 26, 2001·Chemical Reviews·M W Peczuh, A D Hamilton
Mar 29, 2002·Chemistry : a European Journal·Kim B JensenJeremy D Kilburn
Apr 13, 2002·The Journal of Organic Chemistry·Matteo M Conza, Helma Wennemers
Jun 21, 2002·Organic Letters·Stephan Rensing, Thomas Schrader
Jan 18, 2003·Chemistry : a European Journal·Helma WennemersMarkus Neuburger
May 13, 2003·Chemical Communications : Chem Comm·Matteo Conza, Helma Wennemers
Nov 13, 2003·Chembiochem : a European Journal of Chemical Biology·Carsten Schmuck, Martin Heil
Nov 25, 2003·The Journal of Organic Chemistry·Sandra BartoliJeremy D Kilburn
Jun 9, 2004·Current Opinion in Chemical Biology·Natarajan Srinivasan, Jeremy D Kilburn
Jul 22, 2004·Journal of the American Chemical Society·Carsten Schmuck, Lars Geiger
Feb 19, 2005·Chembiochem : a European Journal of Chemical Biology·Carsten SchmuckMartin Heil


Jul 15, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Heike Betat, Mario Mörl
Sep 14, 2006·Chemistry : a European Journal·Carsten SchmuckWolfgang Wienand
Mar 21, 2007·Angewandte Chemie·Gennady V OshovskyWillem Verboom
May 24, 2007·Organic & Biomolecular Chemistry·Richard J FitzmauriceJeremy D Kilburn
Jun 15, 2007·Chemistry : a European Journal·Carsten SchmuckThomas Schrader
Jul 20, 2007·Organic & Biomolecular Chemistry·Carsten Schmuck, Laura Hernandez-Folgado
May 9, 2008·Chemical Communications : Chem Comm·Mikhail V RekharskyYoshihisa Inoue
Sep 22, 2010·Chemistry : a European Journal·Muhammad Irfan AshiqJeremy D Kilburn
Jan 27, 2009·Chemical Society Reviews·Stefan Kubik

Related Concepts

Structure-Activity Relationship
Combinatorial Chemistry Techniques

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.